Progression of chronic diseases in
general and chronic kidney disease in particular has been traditionally
viewed in the light of various contributors to development of
glomerulosclerosis and tubulointerstitial scarring culminating in renal
fibrosis. Indeed, this dogma prevailed for decades underscoring
experimental attempts to halt fibrotic processes. Breakthrough
investigations of the past few years on stem/progenitor cell involvement
in organ regeneration caused a conceptual shift in tackling the
mechanisms of nephrosclerosis. It has become clear that the rate of
progression of chronic kidney disease is the net sum of the opposing
trends: degenerative fibrotic processes and regenerative repair
mechanisms. The latter part of this equation has been by and large
ignored for years and only recently attracted investigative attention.
This book revisits the problem of kidney disease by focusing on
regenerative mechanisms in renal repair and on the ways these
regenerative processes can become subverted by an intrinsic disease
process eventuating in its progression. Cutting-edge investigations are
summarized by the most experienced international team of experts.
* Presents a comprehensive,
translational source for all aspects of renal stem cells, tissue
regeneration, and stem cell therapies for renal diseases in one
reference work. This will ultimately result in time savings
for academic, medical and pharma researchers.
* Experts in the renal stem cell
system in kidney repair and regeneration take readers from the bench
research to new therapeutic approaches, providing a common language for
nephrology researchers, fellows and other stem cell researchers. This
enables the discussion of development of stem cells and their use in the
repair and regeneration of the kidney.
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